chemical genomics

The Infectious Disease Research Institute will use the grant to use "chemical genomics" medium- and high-throughput screening approaches to identify candidate targets against tuberculosis.

The Vancouver Prostate Centre will use funding from Genome BC to conduct computational chemogenomic screening of compounds in a search for new prostate cancer treatments.

BioFocus will provide Genentech with integrated medicinal chemistry, in vitro biology, and ADME services.

The Screen Machine

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Chris Austin has built a world-class chemical genomics facility to develop screening assays for a whole host of biological systems and research purposes. Now he's looking for scientists to make the most of it.

The agency's new strategic plan will turn to 'omics and molecular pathway analysis to understand and monitor environmental toxicity concerns.

Scientists should “be very aware” of the “limitations” of bioluminescent reporters, and contemplate running control assays before interpreting data from high-throughput screens, NCGC researchers said.

Researchers from the National Institutes of Health's Chemical Genomics Center warn that the firefly luciferase enzyme may show enhanced activity with some compounds — potentially leading to false positive results.

Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.

The New York Times reports that evidence linking trauma in one generation to epigenetic effects that influence subsequent generations may be overstated.

ScienceInsider reports that US National Institutes of Health researchers were told in the fall they could not obtain new human fetal tissue.

In PNAS this week: skin pigmentation evolution among KhoeSan, biomarkers for dengue virus progression, and more.