chemical genomics

The Infectious Disease Research Institute will use the grant to use "chemical genomics" medium- and high-throughput screening approaches to identify candidate targets against tuberculosis.

The Vancouver Prostate Centre will use funding from Genome BC to conduct computational chemogenomic screening of compounds in a search for new prostate cancer treatments.

BioFocus will provide Genentech with integrated medicinal chemistry, in vitro biology, and ADME services.

The Screen Machine

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Chris Austin has built a world-class chemical genomics facility to develop screening assays for a whole host of biological systems and research purposes. Now he's looking for scientists to make the most of it.

The agency's new strategic plan will turn to 'omics and molecular pathway analysis to understand and monitor environmental toxicity concerns.

Scientists should “be very aware” of the “limitations” of bioluminescent reporters, and contemplate running control assays before interpreting data from high-throughput screens, NCGC researchers said.

Researchers from the National Institutes of Health's Chemical Genomics Center warn that the firefly luciferase enzyme may show enhanced activity with some compounds — potentially leading to false positive results.

Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.