cell line authentification

No, Not That Line

Retraction Watch speaks with a researcher who hopes to nudge others away from using problematic cell lines.

Researchers profiled the genotypes and phenotypes for more than 700 induced pluripotent stem cell lines, uncovering between-individual sources of variation. 

Short tandem repeat and expression data indicate that the U87MG cell line in the ATCC collection no longer represents the glioma from which it was established.

Considering the widespread use of the cell line, these findings could have significant implications for the research community. 

The firm will provide DNA from at least 50 mouse cell lines for use in a PCR-based validation assay.

NEW YORK (GenomeWeb News) – Promega is suing Life Technologies saying it infringes patents held by Promega covering the analysis of small tandem repeat loci for genetic analysis.

NEW YORK (GenomeWeb News) – Life Technologies has filed a suit asking a federal court to find that the firm does not infringe a patent held by Promega and it has retained rights under a licensing agreement related to cell line authentication and identification.

NPR reports that researchers in Italy are testing a gene drive aimed at controlling mosquito populations.

Researchers may experience the effects of the government shutdown for a while, the Los Angeles Times reports.

A new study finds that the majority of patients at a Tijuana clinic received a diagnosis after first-line genome sequencing, the San Diego Union-Tribune reports.

In Genome Biology this week: post-transcriptional modification-based stratification of glioblastoma, single-cell analysis of gene expression and methylation in human iPSCs, and more.