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CE sequencing

A University of California at Berkeley and Department of Energy Joint Genome Institute-led research team reported today that they have sequenced the genome of a sea sponge, Amphimedon queenslandica, and identified gene families in the genome that are shared with other multicellular animals.

The researchers identified an accumulation of rare variants in four genes identified by GWAS. They now plan to sequence more candidate genes using Sanger sequencing and, eventually, next-generation sequencing.

Researchers from the National Human Genome Research Institute and the University of Alaska at Fairbanks used microsatellite analyses to explore the genetics of Alaskan sled dogs specialized for sprint or distance racing.

By sequencing the genomes of the human body louse and an endosymbiotic bacterial species living inside it, researchers have started finding clues to louse biology and adaptation.

Last year, the consortium, which involves researchers, funding agencies, and industry representatives from Canada, Chile, and Norway, awarded a $6 million contract to Beckman Coulter Genomics for the first phase of the project, which uses Sanger sequencing.

 By genotyping nuclear and mitochondrial sequences from fruit-eating bats in the Caribbean and mainland South America, a Texas Tech University research team has found evidence for hybridization in a Caribbean species called Artibeus schwartzi.

The assay, which combines triplet repeat-primed PCR with high-throughput automated capillary electrophoresis, is fast enough and sensitive enough to serve as the basis for a first-tier routine population screen for fragile X and associated conditions, according to the researchers.

The new sequence data includes 156 new insertions corresponding to novel exons and noncoding regions. The researchers also compared their data to a next-generation sequence and de novo assembled genome, highlighting the advantages and limitations of the newer technology.

American researchers reported today that they have sequenced the genomes of a primary breast tumor, brain metastasis, and matched normal tissue from an African-American woman with basal-like breast cancer as well as a xenograft sample derived from primary tumor tissue.

A Washington University-led research team reported in Nature today that they have sequenced the zebra finch genome.

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US National Institutes of Health Director Francis Collins says he will avoid male-only speaker panels.

Two patients fell ill, and one subsequently died, following a fecal microbiome transplant that harbored multi-drug-resistant bacteria, according to the New York Times.

Technology Review reports that eGenesis is testing whether organs from genetically modified pigs can be transplanted into monkeys.

In Science this week: almond reference genome, and more.