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CE sequencing

The Potato Genome Sequencing Consortium has sequenced and analyzed the genome of a doubled monoploid potato, using this genome to help map sequence reads for a heterozygous diploid potato line.

Persistent will help redesign the software for Life Tech's 3500 Dx Series CE sequencer to meet FDA requirements for clinical use and will be the exclusive provider of tools to integrate third-party assays into the system.

The firms intend to file the software with the US Food and Drug Administration for molecular diagnostic applications.

Transgenomics' CEO said these first forays into next-gen sequencing don't represent a shift in the company's strategy, which has so far been focused on Sanger sequencing and PCR technologies for molecular diagnostics.

Under the agreement, Gen-Probe will commercialize future diagnostic tests — based on DNA sequencing or DNA fragment analysis — that will run on Life Tech's 3500 Dx Genetic Analyzer.

By sequencing and comparing the genomes of the fungal species behind poplar leaf rust and wheat and barley stem rust, researchers are learning more about the genetic strategies that the fungi use to invade and exploit their plant hosts.

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Abbott's CE-Marked Abbott HBV Sequencing test

A clinical research organization will oversee the clinical trials at several independent, accredited HLA typing laboratories in the US. These labs will use the 3500 Dx Genetic Analyzer, SeCore kits, and uTYPE Dx software to analyze six gene regions of the HLA system.

The firm expects to complete the clinical trials this summer and then submit an application with FDA.

An expanded license with Dana-Farber Cancer Institute for an offshoot of its Cold-PCR technology allows Transgenomic to develop kits that can detect mutations in common cancer-related genes such as KRAS and P53 directly from blood samples and then analyze the variants using multiple sequencing approaches.

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Mainichi reports that 43 percent of Japanese individuals said they did not want to eat agricultural products that had been modified using gene-editing tools.

Two US Department of Agriculture research departments are moving to the Kansas City area, according to the Washington Post.

Slate's Jane Hu compares some at-home genetic tests to astrology.

In PLOS this week: analysis of polygenic risk scores for skin cancer, chronic pain GWAS, and more.