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CE sequencing

If approved, Life Tech's assay would be the first sequencing-based HLA typing test to get the FDA green light, and could pave the way for clearance of a next-generation sequencing-based HLA test as well as other approved diagnostics on the 3500.

The Potato Genome Sequencing Consortium has sequenced and analyzed the genome of a doubled monoploid potato, using this genome to help map sequence reads for a heterozygous diploid potato line.

Persistent will help redesign the software for Life Tech's 3500 Dx Series CE sequencer to meet FDA requirements for clinical use and will be the exclusive provider of tools to integrate third-party assays into the system.

The firms intend to file the software with the US Food and Drug Administration for molecular diagnostic applications.

Transgenomics' CEO said these first forays into next-gen sequencing don't represent a shift in the company's strategy, which has so far been focused on Sanger sequencing and PCR technologies for molecular diagnostics.

Under the agreement, Gen-Probe will commercialize future diagnostic tests — based on DNA sequencing or DNA fragment analysis — that will run on Life Tech's 3500 Dx Genetic Analyzer.

By sequencing and comparing the genomes of the fungal species behind poplar leaf rust and wheat and barley stem rust, researchers are learning more about the genetic strategies that the fungi use to invade and exploit their plant hosts.

Abbott's CE-Marked Abbott HBV Sequencing test

A clinical research organization will oversee the clinical trials at several independent, accredited HLA typing laboratories in the US. These labs will use the 3500 Dx Genetic Analyzer, SeCore kits, and uTYPE Dx software to analyze six gene regions of the HLA system.

The firm expects to complete the clinical trials this summer and then submit an application with FDA.

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The Washington Post reports that a Russian Academy of Sciences commission has led to the retraction of hundreds of scientific papers.

The Los Angeles Times' Daily Pilot reports the chief executive of Vantari Genetics has pleaded guilty in a kickback scheme.

News 4 Jax reports that a Florida bill to prevent life and long-term care insurers from using genetic information in their coverage decisions has easily passed one committee.

In Science this week: potentially pathogenic mutations found in hematopoietic stem cells from young healthy donors, and more.