CAR therapies UMiami Researchers to Study Cell Therapy Response in Lymphoma Using WGS, Single-Cell RNA-seq Premium The team has received a $1.5 million US Department of Defense grant to help launch its project on diffuse B-cell lymphoma resistance to CAR T-cell therapy. White House Report Outlines Goals to Advance Genomic Research, Precision Therapy Development The report, on goals for biotechnology and biomanufacturing in the US, suggests areas of investment including multiomics, cell therapies, gene editing, and microbial genome sequencing. Avalon GloboCare, Lu Daopei Hematology Institute Partner to Develop Cell Therapy CDx The deal, which is subject to negotiation, will help Avalon create diagnostics for personalizing its current and future cell immunotherapy programs. New Epigenomic Biomarker Could Predict CAR T-Cell Therapy Resistance in Advanced Childhood Leukemia Premium At AACR, researchers described how pediatric ALL patients who don't respond to anti-CD19 CAR T-cell therapy have cancers with a unique, stem cell-like epigenome. A2 Biotherapeutics Enrolling Patients in Clinical Study of New CAR-T Therapy Using Tempus NGS Panel Premium The Tmod CAR-T platform uses tumor- and non-tumor-specific elements to spare normal cells while killing tumor cells without sacrificing cytotoxic potency. Dec 1, 2021 Sequencing-Based MRD Detection in Bone Marrow May Predict ALL Relapse After CAR T-Cell Therapy Jun 15, 2021 NanoString Technologies, Parker Institute for Cancer Immunotherapy Partner on Cell Therapy Project Feb 25, 2021 CareDx Expanding Diagnostic Tech Into Cell Transplant Monitoring Premium Oct 13, 2020 Twist Bioscience, Neogene Therapeutics Partner to Develop Personalized CAR T Cells, TCR Therapies Breaking News Compact Gene Editing Enzyme May Improve Success Rates of Gene Therapies People in the News at Veracyte, Invitae, Mount Sinai, InterVenn Biosciences, Applied BioCode, More New Products Posted to GenomeWeb: Qiagen, IDT, Revvity, Mission Bio, NRichDx, More FDA Releases Proposed Rule for Oversight of Laboratory-Developed Tests CStone Pharmaceuticals, Genetron Companion Diagnostic Receives NMPA Approval The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.