bisulfite sequencing
Study Reveals Ancestry-Related Differences in Postmortem Brain Gene Activity
Using postmortem brain samples isolated from 151 admixed Black Americans, researchers uncovered immune and vascular genes with ancestry-related expression variation.
Long Reads Perform Well in ABRF, DeCode Genetics Methylation Sequencing Benchmarking Studies
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An ABRF study discovered "spurious" calls in some bisulfite-based methods as well as partial methylation of largely unmethylated controls provided by Zymo Research.
New Resource Combines Functional Genomics, Diploid Genomes for Variant Annotation
Coupling high-quality, long-read genomes with functional assays, researchers tracked the effects of genetic variants across dozens of tissue types in four individuals.
New Enzymatic Approach Enables Transcriptome-Wide N6-Methyladenosine Profiling, Quantification
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The method, dubbed eTAM-seq, offers scientists a new way to study m6A modifications in mRNA at a high resolution while lowering the sample input requirement.
The approach aims to discern environmental DNA contamination by chemically tagging sample-intrinsic cfDNA prior to DNA extraction using bisulfite salt treatment.