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In PNAS this week: possible cancer targets due to homologous recombination defects, approach for detecting digenic disease inheritance, and more.

Transcription factor reprogramming during prostate cancer metastases appears to involve epigenetic changes that resemble those at play during prostate development, new research finds.

While a subset of metastatic castration-resistant tumors was marked by enhanced methylation, the analysis also pointed to recurrently hypomethylated regions.

Dogs age more rapidly in their early years but then age more slowly later on, a DNA methylome analysis found, changing how dogs' ages are translated to human ages.

The firm touts a new hybridization probe design, which it says will enable small, focused panels that reduce sequencing costs and assay time.

The Oxford, UK-based firm announced the closure of a seed financing round this week as well as plans to develop a methylation-based blood test for early-stage cancer detection. 

WUSTL will evaluate BostonGene's software, which integrates data from NGS with immunofluorescence imaging to profile tumors and their microenvironments.

An integrated analysis involving prostate cancer patients from China highlighted frequent FOXA1 mutations and deletions in two other genes.

In PNAS this week: remethylation of DNMT3A in mice affects expansion of myeloid cells, glycan and receptor expression in glioblastoma, and more.

Exome sequencing and other molecular strategies led to a heterogeneous variant in the DNMT3A gene that appears to impact host epigenetic and immune features.

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Novavax has begun a phase III trial of its SARS-CoV-2 vaccine, according to the New York Times.

Vox reports that the Trump Administration may limit student visas for individuals from some countries to two years.

The governor of New York says the state will conduct its own review of any SARS-CoV-2 vaccine, NPR reports.

This week in Science: Neanderthal Y chromosomes replaced by Homo sapiens Y chromosomes, and more.