animal genomics
Cancer May Arise From Epigenetic Changes, Study in Fruit Flies Suggests
Researchers linked transient knockdown of a Polycomb complex component with cancer development and irreversible gene expression changes in developing Drosophila larvae.
Congenital Heart Defect Features of Down Syndrome Spelled Out with Transcriptomics, Mouse Models
Increased DYRK1A gene dosage led to altered expression of mitochondrial and cell proliferation genes in developing cardiac muscle cells, while DYRK1A inhibitors restored activity.
Teams Track Embryo-Wide Development With Single-Cell Transcriptomic Strategies
Researchers used single-cell RNA sequencing and other methods for the large-scale phenotyping of wild type and genetically altered mouse and zebrafish embryos.
Domestic Cat Study Traces Genetic Diversity, Disease Risk Across Breeds
With genotyping data for 11,036 pedigreed or non-pedigreed domestic cats, researchers looked at variation and allele frequencies for disease-, blood type-, or trait-related variants.
Chimpanzee Genetics Offer Clues to Population History, Conservation
With targeted sequencing on fecal samples, researchers retraced chimpanzee population structure and dynamics over time, uncovering genetic markers for chimp geographic origins.