Wide Range of Rare, Common Variants Affect Blood Metabolites

Mar 07, 2017

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NEW YORK (GenomeWeb) – Genetic patterns detected in thousands of twins and unrelated individuals are revealing the wide range of genetic variants that can affect the metabolites found in an individual's blood.

Researchers from the US, the UK, and Singapore combined whole-genome sequencing with liquid chromatography and mass spectrometry-based metabolite profiling on nearly 2,000 individuals to look for genetic variants across the frequency spectrum — from common SNPs to rare variants — that impact blood metabolite patterns.

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