Uveal melanoma, though rare in general, is the most common form of eye cancer — and a highly aggressive one at that. About half of all uveal melanomas that arise metastasize, at which point they're identified as class 2 tumors. Because approximately 90 percent of class 2 tumors — for which there is no treatment and the average patient's life expectancy is less than a year — are associated with monosomy at chromosome 3, the Washington University in St. Louis School of Medicine's Anne Bowcock and her colleagues sought to sequence candidate genes specific to class 2 uveal melanomas there.

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