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TGen to Participate in DoD Program Studying Pharmacogenomics of Breast Cancer

NEW YORK (GenomeWeb News) – The Translational Genomics Reserach Institute will play a "primary" role in a $10.7-million Department of Defense breast cancer research program, the nonprofit said yesterday.
 
The multi-institutional, five-year research program is led by Philadelphia’s Fox Chase Cancer Center. The grant focuses on developing a new treatment model for breast cancer to reverse resistance to anti-estrogen therapy.
 
TGen will collaborate with FCCC and Georgetown University to map the genetic and biological events associated with breast tumor cells and analyze the results to identify patterns consistent with resistance to various anti-hormone therapies.
 
A Johns Hopkins University team will evaluate the patterns under phase I and II clinical studies.
 
The ultimate goal of the study is to exploit the knowledge of measurable similarities shared by drug-resistant breast cancers and translate that knowledge into more accurate prognostic tests and pharmacogenomic treatments.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.