Team Sees Random Mutation Rate Dip in Colon Cancer Mitochondrial DNA | GenomeWeb

NEW YORK (GenomeWeb News) – Colorectal cancer samples have fewer new mutations affecting mitochondrial DNA than do matched normal colon tissues, according to a study appearing online last night in PLoS Genetics.

Researchers from the US and Ireland tested matched tumor-normal samples from 20 individuals with colorectal carcinoma. Along with mitochondrial genome sequencing to look for clonally expanded mutations in the samples, they also relied on a random mutation assay to compare the frequency of non-clonal, random mutations in the mtDNA.

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