Team Develops Bromouridine-Based Sequencing Methods for Following RNA Synthesis and Stability | GenomeWeb

University of Michigan researchers have come up with complementary sequencing-based methods — known as Bru-Seq and BruChase-Seq, respectively — that make it possible to track not only the formation of new RNA molecules, but also their stability within the cell.

The techniques involve replacing one of the four building blocks of RNA — uridine — with another form of the base, called bromouridine.

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