TAB-Seq Method Enables Direct Measurement at Base Resolution of Hydroxymethyl Cytosine | GenomeWeb

While bisulfite sequencing is a proven technique for studying epigenetic changes, it cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine. Now, researchers from the University of Chicago and elsewhere have developed a genome-wide technique for quantifying 5-hmc sites at base resolution.

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