Study Shows 454 Amplicon Sequencing Can Determine Haplotypes from Highly Copy Number Variable Regions | GenomeWeb

By Monica Heger

Researchers from the Leibniz Institute for Age Research at the Fritz Lipmann Institute in Germany have performed a proof-of-principle study demonstrating that 454 amplicon sequencing can determine haplotypes in the beta-defensin locus — a highly variable region of the human genome that harbors variations that have been implicated in a number of diseases.

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