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SOLiD Software Analysis Tools, GenomeQuest 5.0, Metagenomic DNA Isolation Kit

Applied Biosystems has made new, internally developed software analysis tools for its SOLiD system available to researchers. They include a whole-genome color space alignment and read annotation tool; a tool for converting native SOLiD data into the Short Read Format for NCBI submission; a tool for consolidating reference-aligned SOLiD data into the General Feature Format; and an analysis pipeline for aligning small RNA sequence data to the human genome that includes tag counting features. Registered users can download the software here.

GenomeQuest has released GenomeQuest 5.0, a new edition of its high-throughput sequence search, analysis, and data management platform. New features include a new annotation layout, new ways of grouping and saving information, improved reporting, advanced syntax for keyword searching, and a Vector NTI connection.

Epicentre has launched a Metagenomic DNA Isolation kit for water to extract DNA for metagenomic library production. The kit isolates DNA from culturable and unculturable microbes in water samples, including gram-positive bacteria. The isolated DNA can be used immediately for end-repair and cloning into a vector.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.