Single-Stranded DNA Amplification Protocol Key to 15-Fold Coverage Boost for Denisovan Genome | GenomeWeb

A team intent on unraveling the genetic secrets of archaic hominins has come up with a new strategy for amplifying single rather than double strands of DNA, making it possible to sequence ancient genomes to far greater depth than was previously possible.

And because the strategy is specialized for dealing with old and/or somewhat degraded DNA, its developers say it could prove useful not only for sequencing ancient genetic material, but also for performing more sensitive forensic studies.

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