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NEW YORK – In a single-cell analysis of myeloid malignancies, a team led by researchers at Memorial Sloan Kettering Cancer Center has found that acute myeloid leukemia (AML) is dominated by a small number of clones, which frequently harbor co-occurring mutations in epigenetic regulators. Conversely, mutations in signaling genes often occur more than once in distinct subclones, which is consistent with increasing clonal diversity.

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In a letter, about two dozen researchers criticize the World Health Organization investigation into the origins of SARS-CoV-2 and call for a new inquiry, the Wall Street Journal reports.

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