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Sigma-Aldrich, CLC bio

Sigma-Aldrich has launched the Imprint DNA Modification kit, which is based on bisulfite DNA modification technology the company licensed from Epigentek Group, a Brooklyn, NY-based biotechnology company. The new kit completely converts unmethylated cytosine to uracil in less than two hours and requires as little as 50 pg of input DNA. The resulting DNA product is suitable for downstream applications, including qPCR and bisulfite sequencing.

Bioinformatics company CLC bio of Aarhus, Denmark, has released a new software module for Multilocus Sequence Typing. MLST is a portable technique for typing bacteria and yeast isolates. A typical MLST workflow includes assembly, inspection of assembly, trimming of sequence ends, copying and pasting into a web form, and noting the allele number. The new module reduces the time for this workflow from an average 25 minutes to less than a minute, the company said.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.