Sequencing Studies Offer Insight into Impact of Clonal Evolution on Cancer Treatment and Diagnosis | GenomeWeb

By Monica Heger

Cancer has long been known to be a heterogeneous disease, but the extent to which the genomes of cancer cells within a single tumor vary and evolve is just now beginning to be resolved by next-generation sequencing with important implications for therapeutics and diagnosis.

Clonal evolution is "important to cancer biology and important to our understanding of the way we treat cancer," Sam Aparicio of the University of British Columbia and BC Cancer Agency told Clinical Sequencing News.

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