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Sequencing-Related US Patents, Granted May — June 2007

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US Patent 7,232,656. Arrayed biomolecules and their use in sequencing. Inventors: Shankar Balasubramanian, David Klenerman, Colin Barnes, Mark Allen Osborne. Assignee: Solexa.
 
The patent covers a method for analyzing genome-wide variation in an individual based on randomly fragmenting the individual's genome and generating sequence reads of multiple bases on all the fragments, then aligning the sequence reads generated with a known genomic reference sequence, and finally analyzing variations between the sequence reads derived from the individual's genome and a genomic reference sequence.
 

 
US Patent 7,230,093. Method of sequencing by hybridization of oligonucleotide probes. Inventors: Radoje Drmanac, Radornir Crkvenjakov. Assignee: Callida Genomics.
 
The patent describes conditions under which oligonucleotide probes “hybridize preferentially with entirely complementary and homologous nucleic acid targets.” Using these hybridization conditions, overlapping oligonucleotide probes associate with a target nucleic acid. Following washes, positive hybridization signals are used to assemble the sequence of a given nucleic acid fragment. Up to 100,000 probes are used to determine sequence information by simultaneous hybridization with nucleic acid molecules bound to a filter. Additional hybridization conditions are provided that allow stringent hybridization of 6 to 10 nucleotide long oligomers. “Sequence generation can be obtained for a large complex mammalian genome in a single process,” according to the patent abstract.
 

 
US Patent 7,229,799. System and method for nucleic acid sequencing by polymerase synthesis. Inventors: John Williams. Assignee: Li-Cor.
 
The patent covers improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single-molecule detection of fluorescent labeled pyrophosphate moieties released from nucleoside triphosphates as a polymerase extension product is created.
 

 
US Patent 7,229,798. Transposon mediated multiplex sequencing. Inventors: Paul August, Pamela Keagle, Henry Long, Anna Wiencis Montmayeur, Katherine Call, Michael Draper. Assignee: Aventis Pharmaceuticals.
 
The patent protects an automated method of transposon-mediated multiplex sequencing of DNA fragments inserted into a vector. According to the patent abstract, the method offers increase efficiency by screening out constructs in which the transposon inserted into the vector sequence. “This prevents a waste of time and resources in performing reactions sequencing the vector instead of the DNA fragments of interest,” the abstract states.
 

 
US Patent 7,229,767. Genomics applications for modified oligonucleotides. Inventors: Eric Kmiec, Howard Gamper, Michael Rice, Michael Usher. Assignee: University of Delaware.
 
The patent covers methods for producing and using stable complexes of duplex nucleic acid molecules and oligonucleotides. The complexes can be used to detect and purify a known nucleic acid target as well as to manipulate a defined nucleic acid target sequence, according to the patent abstract.

The Scan

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Additional Genes

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Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.