By Monica Heger

This story has been updated from a previous version posted Nov. 12 to include outside comment.

Using whole-genome sequencing in a single patient, researchers at Washington University's Genome Center identified a mutated gene in an acute myeloid leukemia relapse tumor — that they confirmed with targeted sequencing in a larger cohort — that is correlated with a lower survival rate and a more aggressive form of the disease — a finding that they believe could help guide treatment.

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In PNAS this week: spatiotemporal study of lncRNA expression, role of extrachromosomal, circular DNAs in yeast, and more.

A European team has launched a four-year study to develop a test to gauge cervical, ovarian, uterine, or aggressive breast cancer risk in women.

As interest in personalized medicine grows, government contractors are entering the field, the Washington Post reports.

The New York Times editorial board weighs in on scientific research misconduct.