Sequencing of Relapse AML Tumor IDs Mutations in DNMT3A Gene Predictive of Disease Outcome | GenomeWeb

By Monica Heger

This story has been updated from a previous version posted Nov. 12 to include outside comment.

Using whole-genome sequencing in a single patient, researchers at Washington University's Genome Center identified a mutated gene in an acute myeloid leukemia relapse tumor — that they confirmed with targeted sequencing in a larger cohort — that is correlated with a lower survival rate and a more aggressive form of the disease — a finding that they believe could help guide treatment.

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