Sequencing Explains 'Outlier' Patient Response to Everolimus, Shows Promise for Drug Repositioning | GenomeWeb

Sequencing the genome of a cancer bladder patient who responded exceptionally well to a cancer drug that failed in most other patients in a clinical trial, researchers have identified mutations that might serve as predictors of sensitivity to the drug.

The approach – sequencing the tumor genomes of "outlier" patients – might prove useful more generally to salvage cancer drugs that only work in specific patient groups, though pinpointing the right mutations might be challenging.

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