Sequencing the genome of a cancer bladder patient who responded exceptionally well to a cancer drug that failed in most other patients in a clinical trial, researchers have identified mutations that might serve as predictors of sensitivity to the drug.

The approach – sequencing the tumor genomes of "outlier" patients – might prove useful more generally to salvage cancer drugs that only work in specific patient groups, though pinpointing the right mutations might be challenging.

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In Science this week: the Human Silencing Hub protein complex, and more.

Heads of various research funding agencies discuss how to encourage scientific breakthroughs, ScienceInsider reports.

The Kansas City Star examines issues surrounding newborn genome sequencing.

Researchers say their Research Resource Identifier citation format is catching on, Nature News reports.