Sequencing-Based Tropism Testing for HIV May Be Feasible, if Not Yet Commercially Viable | GenomeWeb

By Monica Heger

Sequencing could be used
to detect whether Pfizer's HIV drug Selzentry will be effective for individual patients, according to researchers from the Institute for Immunology and Genetics in Kaiserslautern, Germany.

Testing the ability of Roche's 454 GS FLX to detect viral tropism in HIV, the team sequenced the viruses of 14 patients, selecting specifically for the V3 loop of the virus, the region that allows it to infect human immune cells.

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