Researchers at the Wellcome Trust Sanger Institute have demonstrated that it is possible to sequence DNA on the Pacific Biosciences RS without first doing library preparation. They achieved the best results when the DNA was circular, but found that they could directly sequence linear DNA as well.

Senior author Harold Swerdlow told In Sequence that because the method requires no sample prep and works with limited DNA it could have applications in outbreak scenarios, acute disease detection, metagenomics, and forensics.

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In Nature this week: mouse genome functional analysis, more sensitive chromatin immunoprecipitation, and more.

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