Sanger Team Analyses Suggest Synthetic Associations Not Behind Most Common Disease GWAS Signals | GenomeWeb

By Andrea Anderson

COLD SPRING HARBOR, NY (GenomeWeb News) – Synthetic associations between rare, disease-causing variants and common variants probably explain relatively few of the signals detected in genome-wide association studies of common disease, according to Wellcome Trust Sanger Institute human genetics researcher Jeffrey Barrett.

"The preponderance of evidence suggests they're very unlikely to underlie many GWAS hits," Barrett said.

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