Safety Through Genomics

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"Warning," blares the voice on the television. "This drug may cause drowsiness, dizziness, blurred vision, rapid heartbeat, shortness of breath, upset stomach, hallucinations, loss of sexual function, or death. Do not take if you are pregnant or plan to become pregnant." Sound familiar? Ads for antidepressants warn of the possible risk of suicidal thoughts, while commercials for erectile dysfunction medications notify users of the possibility for uncomfortably prolonged erections. Caveats like these should be recognizable to anyone who has ever taken so much as an aspirin.

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In Science this week: swapping yeast genes with human orthologs to study conservation of function, and more.

Hong Kong is using DNA phenotyping to shame litterers.

A study appearing in Cell suggests some metastatic castration-resistant prostate cancer patients could benefit from PARP inhibitor therapy.

NIH's Francis Collins writes that scientific advances are poised to help populations all over the world, but more scientists are needed to keep the momentum.