Safety Through Genomics

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"Warning," blares the voice on the television. "This drug may cause drowsiness, dizziness, blurred vision, rapid heartbeat, shortness of breath, upset stomach, hallucinations, loss of sexual function, or death. Do not take if you are pregnant or plan to become pregnant." Sound familiar? Ads for antidepressants warn of the possible risk of suicidal thoughts, while commercials for erectile dysfunction medications notify users of the possibility for uncomfortably prolonged erections. Caveats like these should be recognizable to anyone who has ever taken so much as an aspirin.

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In Genome Research this week: multiplex genotyping of germline and somatic short tandem repeats, graph-based regularization, and more.

A lack of funding may lead more than two dozen research facilities in Australia to shut down in three months.

Researchers report that paternally inherited genes are more likely to be expressed in mice.

In PNAS this week: Akt3 amplification in glioma progression, Tibetan Plateau frog genome, and more.