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Researchers Sequence Genome of Mosquito That Carries Yellow, Dengue Fevers

An earlier version of this report erroneously omitted the Broad Institute’s participation in the study.
NEW YORK (GenomeWeb News) — Researchers working with funds from the National Institute of Allergy and Infectious Disease have sequenced the genome of the mosquito that carries viruses responsible for yellow fever and dengue fever, according to the NIAID.
The sequence of the Aedes aegypti was conducted by the J. Craig Venter Institute, the Broad Institute, and by the NIAID's VectorBase bioinformatics resource center.   
The JCVI said the mosquito transmits viruses that cause half a million cases of dengue fever and 30,000 deaths from yellow fever each year. The institute said the sequence is yielding information that could be used to help eradicate the diseases.
The A. aegypti genome contains around 1.38 billion base pairs of DNA, and has an estimated 15,419 protein-encoding genes. The genome has been compared with those of the fruit fly and the Anopheles gambiae mosquito, which were sequenced more than five years ago.
Nearly 50 percent of the genome is made of transposable elements, JCVI said.
The research, which appears in the current issue of Science, shows that A.
gambiae and A. aegypti diverged approximately 150 million years ago.
The institute said it has found proteins and genes in the A. aegypti genome that "infer robustness" and that are unique to the species. These genes may therefore help researchers devise ways to arrest the spread of these diseases.  
Vishvanath Nene, JCVI's lead investigator of the project, said that having A. aegypti's sequence will help identify pathways that permit these mosquitoes to transmit the viruses.
"Interfering with the function of critical mosquito molecules could lead to effective control of this prolific pest and the devastating diseases associated with it," Nene said in a statement.

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