Researchers Find Functional Information in DNA Topography | GenomeWeb

It's not just what a DNA sequence says, but how it looks. NHGRI's Elliott Margulies and Boston University's Thomas Tullius found that certain topographical features of a stretch of DNA — particularly when conserved across species — are correlated to its function. "When we think of primary sequences being conserved throughout evolution, we think that those sequences are maintained because they do some important function. And now we are extending that onto the structural topography of DNA," Margulies says.

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