Researchers Beware: Sequencing-Based DGE Profiling of Small RNA is Biased, Study Says | GenomeWeb

By Julia Karow

A research team led by the Hubrecht Institute and the University Medical Center Utrecht in the Netherlands has found that current sequencing-based methods for small RNA digital gene expression profiling are strongly biased towards certain types of small RNAs.

The findings could limit the use of these results for absolute measurements of small RNAs, the researchers said, despite the fact that the methods are "digital."

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