A team from the US and Singapore has come up with a method for nearly doubling Illumina read lengths using overlapping libraries, producing reads that approach the 500 base pair mark.

The strategy relies on the production of "contiguous" reads from two shorter sequences that overlap by a few dozen bases, in some experiments, or by just a handful of bases in the case of the most well-characterized samples, explained Stephan Schuster, a researcher affiliated with Pennsylvania State University and Singapore's Nanyang Technological University.

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