Proof-of-Principle Study Shows MspA Is Superior to Alpha-Hemolysin for Protein Nanopore Sequencing | GenomeWeb

By Monica Heger

Efforts to sequence
DNA by threading it through protein-based nanopores have traditionally relied on one protein: alpha-hemolysin. But researchers from the University of Washington have diverged from that route, demonstrating in a recent proof-of-principle study that engineered Mycobacterium smegmatis porin A could yield a superior nanopore.

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