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In Print: Last Week's Sequencing-Related Papers of Note: Feb 21, 2012


Detection of a possible bioterrorism agent, Francisella sp., in a clinical specimen using next-generation direct DNA sequencing.
Kuroda M, Sekizuka T, Shinya F, Takeuchi F, et al.
J Clin Microbiol. 2012 Feb 15. [Epub ahead of print]

GemSIM: General, error-model based SIMulator of next-generation sequencing data.
McElroy KE, Luciani F, Thomas T.
BMC Genomics. 2012 Feb 15;13(1):74.

Positional correlation analysis improves reconstruction of full-length transcripts and alternative isoforms from noisy array signals or short reads.
Kawaguchi S, Iida K, Harada E, Hanada K, et al.
Bioinformatics. 2012 Feb 13. [Epub ahead of print]

Identification of novel microRNAs in Hevea brasiliensis and computational prediction of their targets.
Gebelin V, Argout X, Engchuan W, Pitollat B, et al.
BMC Plant Biol. 2012 Feb 13;12(1):18.

Comparative analysis of different label-free mass spectrometry based protein abundance estimates and their correlation with RNA-seq gene expression data.
Ning K, Fermin D, Nesvizhskii AI.
J Proteome Res. 2012 Feb 13. [Epub ahead of print]

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.