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In Print: Last Week's Clinical Sequencing Papers of Note: Dec 14, 2011


Disclosing pathogenic genetic variants to research participants: Quantifying an emerging ethical responsibility.
Cassa CA, Savage SK, Taylor PL, Green RC, et al.
Genome Res. 2011 Dec 6. [Epub ahead of print]

Exome sequencing and SNP analysis detect novel compound heterozygosity in fatty acid hydroxylase-associated neurodegeneration.
Pierson TM, Simeonov DR, Sincan M, Adams DA, et al.
Eur J Hum Genet. 2011 Dec 7. [Epub ahead of print]

Genomics and privacy: implications of the new reality of closed data for the field.
Greenbaum D, Sboner A, Mu XJ, Gerstein M.
PLoS Comput Biol. 2011 Dec;7(12):e1002278.

ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches.
Li H, Bitler BG, Vathipadiekal V, Maradeo ME, et al.
Cancer Prev Res (Phila) . 2011 Dec 5. [Epub ahead of print]

Assembly and characterization of pandemic influenza A H1N1 genome in nasopharyngeal swabs using high-throughput pyrosequencing.
Bartolini B, Chillemi G, Abbate I, Bruselles A, et al.
New Microbiol. 2011 Oct;34(4):391-7.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.