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In Print: Last Week's Clinical Sequencing Papers of Note: Mar 14, 2012


Automating HIV drug resistance genotyping with RECall, a freely accessible sequence analysis tool.
Woods CK, Brumme CJ, Liu TF, Chui CK, et al.
J Clin Microbiol. 2012 Mar 7. [Epub ahead of print]

Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.
Warren LL, Li L, Nelson MR, Ehm MG, et al.
Diabetes. 2012 Mar 8. [Epub ahead of print]

Next-generation DNA re-sequencing identifies common variants of TYR and HLA-A that modulate the risk of generalized vitiligo via antigen presentation.
Jin Y, Ferrara T, Gowan K, Holcomb C, et al.
J Invest Dermatol. 2012 Mar 8. [Epub ahead of print]

De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer.
Wu X, Somlo G, Yu Y, Palomares MR, et al.
J Transl Med. 2012 Mar 8;10(1):42.

A modified method for whole exome resequencing from minimal amounts of starting DNA.
Kozarewa I, Rosa-Rosa JM, Wardell CP, Walker BA, et al.
PLoS One. 2012;7(3):e32617.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Gerlinger M, Rowan AJ, Horswell S, Larkin J, et al.
N Engl J Med. 2012 Mar 8;366(10):883-92.

Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery.
Li H, Zhou H, Wang D, Qiu J, et al.
Proc Natl Acad Sci U S A. 2012 Mar 6. [Epub ahead of print]

Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutation.
Hedberg C, Melberg A, Kuhl A, Jenne D, Oldfors A.
Eur J Hum Genet. 2012 Mar 7. [Epub ahead of print]

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance.
Shi H, Moriceau G, Kong X, Lee MK, et al.
Nat Commun. 2012 Mar 6;3:724.

Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.
Auburn S, Campino S, Miotto O, Djimde AA, et al.
PLoS One. 2012;7(2):e32891.

In-depth characterization of viral isolates from plasma and cells compared with plasma circulating quasispecies in early HIV-1 infection.
Dalmau J, Codoñer FM, Erkizia I, Pino M, et al.
PLoS One. 2012;7(2):e32714.

Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease.
Young BC, Golubchik T, Batty EM, Fung R, et al.
Proc Natl Acad Sci U S A. 2012 Mar 5. [Epub ahead of print]

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.