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Papers of Note: Feb 22, 2011


The draft genome of the parasitic nematode Trichinella spiralis.
Mitreva M, Jasmer DP, Zarlenga DS, Wang Z, et al.
Nat Genet. 2011 Feb 20. [Epub ahead of print]

Confounded by sequencing depth in association studies of rare alleles.
Garner C.
Genet Epidemiol. 2011 Feb 16. doi: 10.1002/gepi.20574. [Epub ahead of print]

Global analysis of disease-related DNA sequence variation in 10 healthy individuals: Implications for whole genome-based clinical diagnostics.
Moore B, Hu H, Singleton M, Reese MG, et al.
Genet Med. 2011 Feb 15. [Epub ahead of print]

Identifying dispersed epigenomic domains from ChIP-seq data.
Song Q, Smith AD.
Bioinformatics. 2011 Feb 16. [Epub ahead of print]

Exome sequencing links gene mutation in angiopoietin-like protein 3 with low-density lipoprotein cholesterol.
Glazer NL.
Circ Cardiovasc Genet. 2011 Feb 1;4(1):100-1.

Subunit dimers of {alpha}-hemolysin expand the engineering toolbox for protein nanopores.
Hammerstein AF, Jayasinghe L, Bayley H.
J Biol Chem. 2011 Feb 15. [Epub ahead of print]

Sequence-based physical mapping of complex genomes by whole genome profiling.
van Oeveren J, de Ruiter M, Jesse T, van der Poel H, et al.
Genome Res. 2011 Feb 1. [Epub ahead of print]

CNVnator: An approach to discover, genotype and characterize typical and atypical CNVs from family and population genome sequencing.
Abyzov A, Urban AE, Snyder M, Gerstein M.
Genome Res. 2011 Feb 7. [Epub ahead of print]

High-throughput 454 resequencing for allele discovery and recombination mapping in Plasmodium falciparum.
Samarakoon U, Regier A, Tan A, Desany BA, et al.
BMC Genomics. 2011 Feb 17;12(1):116.

Sensitive gene fusion detection using ambiguously mapping RNA-seq read pairs.
Kinsella M, Harismendy O, Nakano M, Frazer KA, Bafna V.
Bioinformatics. 2011 Feb 16. [Epub ahead of print]

Detecting common copy number variants in high-throughput sequencing data by using JointSLM algorithm.
Magi A, Benelli M, Yoon S, Roviello F, Torricelli F.
Nucleic Acids Res. 2011 Feb 14. [Epub ahead of print]

Improving SNP discovery by base alignment quality.
Li H.
Bioinformatics. 2011 Feb 13. [Epub ahead of print]

The salt-responsive transcriptome of chickpea roots and nodules via deepSuperSAGE.
Molina C, Zaman-Allah M, Khan F, Fatnassi N, Horres et al.
BMC Plant Biol. 2011 Feb 14;11(1):31.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.