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NEW YORK (GenomeWeb) – A Memorial Sloan Kettering Cancer Center-led team has started documenting the role that whole-genome doubling (WGD) may play in the dynamics of different cancer types and subtypes.

The researchers prospectively generated targeted sequence data for nearly 10,000 advanced cancer cases, identifying WGD in almost one-third of the tumors. Their follow-up analyses suggested these WGD events often occurred relatively early on in the cancer development process, arising more frequently in tumors from certain lineages or cancer subtypes. 

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