PacBio, U Chicago Develop Single-Molecule Hydroxymethylation Sequencing Technique

Dec 06, 2011

Premium

Researchers at the University of Chicago have combined a chemical labeling method for 5-hydroxymethylcytosine with sequencing on the Pacific Biosciences RS, allowing for single-base resolution of the epigenetic marker, which is involved in cell development and may play a role in some human disease.

Get the full story with
GenomeWeb Premium

Only $95 for the
first 90 days*

GenomeWeb Premium gives you:
✔ Full site access
✔ Interest-based email alerts
✔ Access to archives

Never miss another important industry story.

Try GenomeWeb Premium now.

You may already have institutional access!

Check if I qualify.

Already a GenomeWeb or 360Dx Premium member?
Login Now.

*Before your trial expires, we’ll put together a custom quote with your long-term premium options.

Not ready for premium?

Register for Free Content
You can still register for access to our free content.

Breaking News

The Scan

Diversity of African Genomes

New research shows that scientists need to do a better job of including a wider diversity of African genomes in their analyses, STAT says.

'We Gotta Change These Numbers'

A new paper in Science shows that men are still winning a large majority of the most sought-after NIH grants.

Science Like a Girl

Nature Research and the Estée Lauder Companies are awarding efforts to encourage girls to pursue careers in the STEM fields.

Science Looks at Beneficial Genetic Variants in the Melanesian Population, and More

In Science this week: beneficial genetic variants inherited from archaic Neanderthal and Denisovan hominins, and more.

Featured White Papers

The 'Dark Matter' of Cancer Genomics: Revealing Undetected Structural Variants

Analytical Validation of the Oncomine Pan-Cancer Cell-Free Assay

A High-Performance Solution Combining CleanPlex OncoZoom Cancer Hotspot Panel and SOPHiA AI for Rapid Characterization of Somatic Mutations

BlueBee Data Security & Compliance

Oct

23

Featured Webinar

Single-Cell Methylation Profiling of Pediatric Tumors via a Unique NGS-based Approach

This webinar will illustrate how single-cell methylation sequencing can be applied to gain significant insight into epigenetic heterogeneity in disease states, advancing cancer research discoveries.

Oct

31

Featured Webinar

The Power of Automation for NGS Capture Enrichment: Uniformity and Speed

This webinar will provide an overview of how the Center for Applied Genomics at Children's Hospital of Philadelphia has optimized its next-generation sequencing (NGS) workflow using a combination of PerkinElmer's Sciclone automation technology and target capture chemistry from Twist Bioscience.

Menu