Pacific Biosciences has used its single-molecule technology to sequence the 4.6-megabase genome of E. coli and has generated reads several thousand bases in length, a company official said last week.

At the Advances in Genome Biology and Technology conference in Marco Island, Fla., last week, PacBio Chief Technology Officer Steve Turner presented results from this and an earlier project, in which company researchers sequenced a human bacterial artificial chromosome.

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