Oxford Group Engineers Protein Nanopore for Better Base Recognition, DNA Methylation Detection | GenomeWeb

By Monica Heger

Researchers have demonstrated that an alpha-hemolysin nanopore can identify epigenetic modifications of DNA, suggesting that eventually, nanopores will be able to perform single-molecule methylation sequencing of a DNA strand — an advance over current methylation sequencing methods, such as bisulfite sequencing, which require the DNA to be modified or amplified.

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