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NimbleGen Sequence Capture, SOLiD RNA Expression Solution, GQ HTm

Roche NimbleGen has launched its NimbleGen Sequence Capture technology as a service. The technology enables scientists to select targeted regions of the genome for high-throughput sequencing. It can capture up to five million targeted bases from the human or mouse genome. Researchers can target either contiguous or dispersed genomic regions. The company said it plans to make the capture arrays and related reagents and instruments available “soon” to customers worldwide.

Applied Biosystems has launched SOLiD RNA Expression Solution, a new sample preparation kit to prepare RNA for the SOLiD sequencing system. The new kit is currently available through an early-access program.

GenomeQuest has launched a high-throughput module for its sequence search, analysis, and data management platform. The module, GQ HTm, consists of GQ High Throughput Extension, or GQ HTx, and GQ High Throughput Reporting, or GQ HTr.
GQ HTx facilitates “all-against-all” sequence database searches via command-line workflows sent directly to the GenomeQuest server. Users can analyze thousands of sequence queries simultaneously, access aggregated database content, and develop workflows.
GQ HTr organizes, analyzes, and reports results from multiple sequence queries in the GenomeQuest web interface. Results are grouped by query, subject, patent, gene name or organism, and sorted as needed.
Other enhancements include improved keyword searching with word proximity, phrase searching, and “wild card” operator; GQ Gene, a high-resolution gene database for human, rat and mouse genes with associated gene viewer; DrugBank Pro database including info on IND’s; and the availability of GenBank 164 and additional WIPO patents from paper filings.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.