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NIAID, NHGRI Seeking New Pathogens for Sequencing

NEW YORK (GenomeWeb News) – The National Institutes of Health is seeking nominations from the scientific community for pathogens or invertebrate vectors that carry pathogens for genome sequencing.

The National Institute of Allergy and Infectious Diseases and the National Human Genome Research Institute plan to sequence more eukaryotic pathogens and vectors, and are currently seeking "the widest possible community input" on the choice of their next sequencing targets.

NIAID and NHGRI have commissioned the Human Pathogens and Disease Vectors Sequencing Target Selection Working Group to identify priorities for such sequencing projects. So far, the group has submitted white papers for its first three priority organisms, including Plasmodium, Trypanosome, and Anopheles, all of which have been approved for sequencing.

A limited number of eukaryotic pathogens and invertebrate vectors have been sequenced so far, and NIH sees a need for continuing to pursue more of both types of organisms.

NHGRI and NIAID expect to review recommended sequencing targets three times per year, and priority will be given to pathogens and vectors that are considered to be of "high clinical and biomedical significance."

The targets chosen by NIAID and NHGRI will be proposed for sequencing through white papers that provide defined sequencing targets, scientific rationale, and suggested sequencing strategy. Those papers will be evaluated by the working group and submitted to the NHGRI Advisory Council and the NIAID Genome Sequencing Centers for final approval.

White papers will be approved based on "the proposed targets' clinical and biomedical significance and technical feasibility for genomic sequencing, sample availability, as well as availability of sequencing capacity at the NHGRI and NIAID-funded Sequencing Centers," the institutes said.

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