Skip to main content
Premium Trial:

Request an Annual Quote

NIAID, NHGRI Seeking New Pathogens for Sequencing

NEW YORK (GenomeWeb News) – The National Institutes of Health is seeking nominations from the scientific community for pathogens or invertebrate vectors that carry pathogens for genome sequencing.

The National Institute of Allergy and Infectious Diseases and the National Human Genome Research Institute plan to sequence more eukaryotic pathogens and vectors, and are currently seeking "the widest possible community input" on the choice of their next sequencing targets.

NIAID and NHGRI have commissioned the Human Pathogens and Disease Vectors Sequencing Target Selection Working Group to identify priorities for such sequencing projects. So far, the group has submitted white papers for its first three priority organisms, including Plasmodium, Trypanosome, and Anopheles, all of which have been approved for sequencing.

A limited number of eukaryotic pathogens and invertebrate vectors have been sequenced so far, and NIH sees a need for continuing to pursue more of both types of organisms.

NHGRI and NIAID expect to review recommended sequencing targets three times per year, and priority will be given to pathogens and vectors that are considered to be of "high clinical and biomedical significance."

The targets chosen by NIAID and NHGRI will be proposed for sequencing through white papers that provide defined sequencing targets, scientific rationale, and suggested sequencing strategy. Those papers will be evaluated by the working group and submitted to the NHGRI Advisory Council and the NIAID Genome Sequencing Centers for final approval.

White papers will be approved based on "the proposed targets' clinical and biomedical significance and technical feasibility for genomic sequencing, sample availability, as well as availability of sequencing capacity at the NHGRI and NIAID-funded Sequencing Centers," the institutes said.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.