NEW YORK (GenomeWeb News) - The National Human Genome Research Institute has set aside approximately $2 million in fiscal year 2007 under two requests for applications to develop new technologies to determine functional elements in eukaryotic genomes.
The reissue splits the original RFA, released Jan. 6, 2004, into two separate RFAs: one for the R21 grant mechanism and the other for the R01 grant mechanism.
NHGRI said it would fund six to 10 new and/or competing continuation grants “to develop new and improved technologies for the efficient, comprehensive and high-throughput identification and validation of all types of sequence-based functional elements in eukaryotic genomes.”
The development effort is part of the Encyclopedia of DNA Elements Project, which attempts to identify all of the functional elements in the human genome.
The NIH agency will support “the development of novel technologies and expand the available toolbox of methods that will comprehensively identify sequence-based functional elements in eukaryotic genomes in a high-throughput manner,” the RFA said.
The RFAs cover:
- Transcribed sequences, with the emphasis on non-protein-coding transcribed sequences;
- Conserved non-coding sequences that represent functional elements;
- Cis-acting elements that regulate gene expression at either the transcriptional or post-transcriptional levels;
- Sequence features that affect or control various aspects of chromosome biology, including chromatin structure;
- Epigenetic changes, such as DNA methylation and chromatin modifications; and
- Functional elements in repetitive sequences.
Applicants may request a project period of up to three years and a budget for direct costs up to $350,000 per year, NHGRI said.
Letters of intent should be received by Oct. 30 and applications should be received by Nov. 28, according to NHGRI. Earliest anticipated start date is June 1, 2007.
Additional information for the R21 grant mechanism can be found here.
Additional information for the R01 grant mechanism can be found here.