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NHGRI, Rett Syndrome Foundation Award $550K to Genome Institute of Singapore for Sequencing Projects

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This article was originally published Oct. 22.

The Genome Institute of Singapore said last week that it has recently secured a total of $550,000 in funding from the International Rett Syndrome Foundation and the National Human Genome Research Institute for sequencing projects.

The NHGRI grants are extensions of previous grants awarded under the ENCODE project, totaling $450,000. The grant from the International Rett Syndrome Foundation, worth $100,000, supports the use of a method developed by senior group leader Yijun Ruan to study the gene involved in the developmental disease Rett syndrome.

One of NHGRI's grant extensions, worth $300,000, supports the use of Ruan's sequencing method, chromatin interaction analysis using paired-end ditagging, or ChIA-PET, to generate three-dimensional datasets of human genome conformation. ChIA-PET enables chromatin mapping by use of high-throughput sequencing. The grant was originally awarded in 2007 (IS 11/30/2007).

The second NHGRI grant, totaling $150,000, is an extension of a project to characterize and classify the human transcriptome, a project now in its fourth year.

Additionally, Ruan's team received $100,000 from the International Rett Syndrome Foundation to use ChIA-PET to study disease mechanisms involved in Rett syndrome, an X-linked developmental disorder that affects girls' ability to walk, eat, and talk.

MeCP2 is the gene that has been implicated in the disorder, and Ruan will use the ChIA-PET method to "interrogate the gene function regulatory networks involving MeCP2 with the aim of understanding the disease mechanism and finding a cure," Ruan said in a statement.

The International Rett Syndrome Foundation grant begins this month and will last for two years.

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