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NextGENe, End-it DNA End Repair Kit, GenElute HP 96-Well Plasmid Miniprep Kit

SoftGenetics has released a new version of its NextGENe software, which has improved SNP and indel detection capabilities. The new version includes a patent-pending condensation tool that “statistically polishes the data” by removing chemistry- and instrument-related errors, sorting the raw data by a 12-base anchor sequence and sequence shoulders, and assembling it by further condensation cycles, according to the company. The software can use data from Illumina’s Genome Analyzer, 454 Life Sciences, and Applied BiosystemsSOLiD platform. NextGENe analysis modules include SNP/indel detection, de novo and target assembly, digital gene expression analysis, transcriptome analysis, ChipSeq analysis, and miRNA discovery and quantification. Interested parties can request a free 30-day evaluation or schedule a web-based review meeting.

Epicentre Biotechnologies has released its End-It DNA end repair kit for treating fragmented genomic DNA for use in next-generation DNA sequencing. The kit converts DNA containing damaged or 5′ and/or 3′ protruding ends to 5′-phosphorylated, blunt-ended DNA for ligation to sequencing adaptors. The kit contains reagents for 20 end-repair reactions, up to 100 micrograms of genomic DNA. The kit can be combined with Epicentre’s Fast-Link DNA ligation kit.

Sigma-Aldrich has launched its GenElute HP 96-well plasmid miniprep kit for DNA purification. The kit allows for rapid purification of plasmid DNA to transfection-grade quality. Up to 10 micrograms of high-copy plasmid DNA can be recovered per well from 1.3 milliliters of harvested bacterial culture in less than 50 minutes, according to the company. The kit is compatible with automated liquid handling workstations and offers a vacuum manifold-based manual protocol.

The Scan

Just Breathing

A new analysis suggests that most Mycobacterium tuberculosis is spread by aerosols from breathing, rather than by coughing, the New York Times reports.

Just Like This One

NPR reports that the World Health Organization has hired a South African biotech company to recreate mRNA vaccine for SARS-CoV-2 that is similar to the one developed by Moderna.

Slow Start

The Wall Street Journal reports that Biogen's Alzheimer's disease treatment had revenues for July through September that totaled $300,000.

Genome Research Papers on Cancer Chromatin, Splicing in the Thymus, Circular RNAs in Cancer

In Genome Research this week: analysis of bivalent chromatin sites, RBFOX splicing factors' role in thymic epithelial cells, and more.