New Studies Link Rare Variant to Alzheimer's Disease Risk | GenomeWeb

NEW YORK (GenomeWeb News) – A pair of studies that appeared in The New England Journal of Medicine this week identified a rare variant of the TREM2 gene as a potent risk factor for late-onset Alzheimer's disease.

A number of risk variants for Alzheimer's disease have previously been reported, though many of them have been linked to familial early-onset Alzheimer's disease, while others that have been associated with the late-onset form of the disease have generally been shown to confer low risk, with the notable exception of the ε4 allele of apolipoprotein E.

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