New Sequencing Approach Examines Specific RNA Epigenetic Modifications

NEW YORK (GenomeWeb) – Researchers from Boston and Los Angeles have devised a new sequencing approach to gauge N⁶-methyladenosine modifications of RNA molecules.

N⁶-methyladenosine (m⁶A) is a reversible chemical modification of mRNAs and long noncoding RNAs. While such modifications have been linked to RNA metabolism, not much is known about how common modified transcripts are and what their regulatory effect is, the researchers noted.