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New Products: Zymo's Methyl-Seq and 5-hmC Prep Kits; Gene Codes' Sequencher 5.2

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Zymo Research Corporation has launched Pico Methyl-Seq Library Prep and RRHP 5-hmC Library Prep kits for next-gen sequencing-based analysis of 5-methylcytosine and 5-hydroxymethylcytosine, respectively. The kits are compatible with next-gen sequencing on Illumina platforms. The Pico Methyl-Seq kit is a modified whole-genome bisulfite sequencing library prep workflow that can be completed in less than six hours, according to the company. The RRHP 5-hmC kit uses a reduced representation hydroxymethylation profiling protocol that requires 100 ng of input DNA, is quantitative and strand-specific.


Gene Codes Corporation has released Sequencher 5.2, the latest release of its DNA sequencing software that can analyze both Sanger sequencing data and next-gen sequencing data. A new addition to the software is Sequencher Connections, which integrates Sequencher with third-party tools.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.