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New Products: University of Washington's UW-Onco-Plex; Sequenta's ClonoSight; LifeCodexx's PrenaTest


The University of Washington and Seattle Cancer Care Alliance have launched UW-Onco-Plex, a sequencing-based test to help guide treatment for cancer patients. The test uses the Illumina platform to analyze 194 genes associated with cancer. Doctors can order the test for their patients and turnaround time is approximately two months.

Sequenta has launched ClonoSight, its sequencing-based test to measure minimal residual disease in leukemia and lymphoma patients. The test is based on the company's proprietary LymphoSight technology, which targets unique DNA signatures that are present in immune cells. Its validation studies found that it could detect disease in as many as 10 percent of children with acute lymphoblastic leukemia that were found to be negative by flow cytometry.

GATC Biotech subsidiary LifeCodexx has launched an expanded version of its PrenaTest. The noninvasive, sequencing-based fetal aneuploidy test can now detect not only trisomy 21, but also trisomies 18 and 13.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.