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New Products: Trovagene's KRAS Test; Emory's Medical EmExome

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Trovagene has launched a next-generation sequencing-based assay to test for KRAS oncogene mutations by assessing the urine of metastatic cancer patients with biopsy-proven KRAS mutations in their tumor.

The assay is designed to detect the seven most prevalent mutations in the KRAS oncogene and has a lower limit of detection of .04 percent, according to the company.


Emory Genetics Laboratory has launched the Medical EmExome, an exome sequencing test with enhanced coverage off 4,600 medically relevant genes. The test will cost $6,000 or $6,700 for a trio (see story, this issue).

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.